ABSTRACT
PURPOSE: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer. MATERIALS AND METHODS: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion. RESULTS: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p=0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726). CONCLUSIONS: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer.
Subject(s)
Humans , Biopsy , Multivariate Analysis , Neoadjuvant Therapy , Neoplasm Grading , Neoplasm Invasiveness , Peripheral Nerves , Prognosis , Prostate , Prostatectomy , Prostatic Neoplasms , Recurrence , Retrospective StudiesABSTRACT
A foreign body near the bladder is rare. Although foreign bodies in the bladder can be easily found and removed by endoscopic transurethral removal, extravesical foreign bodies may require the use of an open or laparoscopic procedure. Here, we report a case of a patient complaining of frequency and urgency in whom an extravesical sewing needle was successfully removed by a laparoscopic approach. A 4.5 cm rusty sewing needle was found between the bladder and the left external iliac vessels and was removed through a 5 mm trocar port by use of endo forceps with no complications.
Subject(s)
Humans , Foreign Bodies , Laparoscopy , Needles , Surgical Instruments , Urinary BladderABSTRACT
PURPOSE: The goal of this study was to investigate the impact on quality of life of urinary incontinence and to examine its relationship with treatment need in community women according to the frequency of stress urinary incontinence(SUI) and SEAPI score. MATERIALS AND METHODS: In 554 of total 811 women, a questionnaire survey was conducted in a typical farming village of a southern region of Korea. The frequencies of SUI were divided into 5 groups(A, less than 12 times/year; B, less than 4 times/month; C, 1 time/week; D, more than 2 times/week; and E, more than 1 time/day) and the SEAPI score into 3 groups according to the sum of all categories(a, 0-5; b, 6-10; and c, 11-15). Each objective criterion was compared with the responders' quality of life indices, cognition indices about symptom and acception indices of treatment. RESULTS: Of the 554 participants, 274(49.5%) had experienced SUI at least once in the last year. In the study of influences on quality of life according to the frequency of SUI and SEAPI score, statistically significant correlations were noted from groups C and b about daily life and social life categories(p<0.05), but not in the sexual life category. Groups E and b had statistically significant correlation in the influences on cognition of symptom(p<0.05). Groups C and b had statistically significant correlation in the influences on the acceptance of treatment (p<0.05). CONCLUSIONS: In spite of its great effect on quality of life, SUI has hardly induced community women to accept the need for its treatment. These findings suggest that more medical education and information about SUI should be offered. These preliminary results may be used as quality of life indices, cognition indices about symptoms and acception indices in future SUI surveys.
Subject(s)
Female , Humans , Cognition , Education, Medical , Korea , Quality of Life , Surveys and Questionnaires , Urinary Incontinence , Urinary Incontinence, StressABSTRACT
Leiomyosarcoma of the penis is an extremely rare disease. We experienced a patient with a leiomyosarcoma on the ventral preputial skin of penis in a 45-year old man. The patient was treated with local wide excision with chemotherapy. Herein, we report this case with the review of literature.